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6. Morales A, Gingell C, Collins M, Wicker PA, Osterloh IH. Clinical safety of oral sildenafil citrate (Fildena®) in the treatment of erectile dysfunction. Erections also were achieved when VSS was delayed for 2 or 4 h after patients received 100-mg doses of sildenafil. When VSS commenced 4 h after dosing, the median total duration of grade 3 or 4 erections in patients receiving sildenafil was 5.0 min (range 0-45 min), and the overall mean was 13.9±4.0 min, whereas in patients receiving placebo, the median total duration was 0 min (range 0-27 min), and the mean was 2.9±1.9 min (P < 0.01; Figure 2b, 2d ). The proportion of treatment responders was significantly greater among patients receiving sildenafil (13 of 16 patients, 81%) compared with patients receiving placebo (five of 16 patients, 31%; P < 0.05).
Among all patients treated with sildenafil, the median duration of grade 3 or 4 erections was 10.0 min (range 0-60 min) and the adjusted mean was 15.8 min, compared with a median of 0 min (range 0-20 min) and an adjusted mean of 2.4 min for patients treated with placebo (anova, P < 0.001 for treatment effect) http://comfortcareco.com/.
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